Extended-Spectrum β-lactamases and AmpC Production among Uropathogenic Isolates of Escherichia coli and Antibiogram Pattern

Aryan R. Ganjo

doi:10.14500/aro.10898

Aryan R. Ganjo Department of Pharmacognosy, College of Pharmacy, Hawler Medical University Erbil, Kurdistan Region – F.R. Iraq https://orcid.org/0000-0002-1141-9435

Keywords: AmpC, ESBL, Escherichia coli, Urinary tract infections

Abstract

Emergence of drug resistance in Escherichia coli due to various mechanisms makes the treatment choices very limited. The objective of this research was to investigate extended-spectrum beta-lactamases (ESBLs) and AmpC lactamases in E. coli isolates from urinary tract infections (UTIs) and to assess their antibacterial susceptibility patterns in a health-care context. Atotal of 70 E. coli isolates from clinically assumed cases of UTI patients during the 9months period. The isolates with bacteriuria (105 CFU/ml) were identified. ESBL and AmpC were detected phenotypically. Out of the 70 isolates of uropathogenic E. coli, ESBL production was detected in 34(48.6%) isolates and AmpC producer in 27(38.6%) of isolates in which 14(20%) of them showed coexistence phenotype of both ESBLs and AmpC and 23(32.9%) E. coli isolates were both ESBL and AmpC non-producer. The findings donated information regarding drug resistance. The level of resistance recorded in ESBL-and AmpC-producing uropathogenic E. coli of this study was raising; therefore, it is crucial to have a strict infection control measures and routine monitoring of ESBL-and AmpC-producing bacteria in clinical laboratory.

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Author Biography

Aryan R. Ganjo, Department of Pharmacognosy, College of Pharmacy, Hawler Medical University Erbil, Kurdistan Region – F.R. Iraq

Aryan R. Ganjo is a Assistant Prof. at the Department of Pharmacognosy, Faculty/College of Pharmacy, Hawler Medical University. She got the B.Sc. degree in Biology, the M.Sc. degree in Microbiology and the Ph.D. degree in Medical Microbiology. Her research interests are in Molecular biology, Bacterial Genetics and infectious disease.

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